5 research outputs found

    Integration of virtual and real document organization

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    In most work environments people archive both the real and digital versions of their documents. But unlike the digital world, in the physical world locating a document can become a very time consuming task. The reason for this is the lack of a direct connection between the physical and digital versions of documents. The Smart Filing System combines the benefits of the digital and the real world providing an augmented filing cabinet. The system benefits by linking the physical world with the digital desktop world. In our setup, we implemented an add-in for MS OneNote™. Furthermore, real folders and cabinets are extended with devices for direct input and output. This allows us to search and browse through digital documents using MS OneNote™. Simultaneously, our system also allows a feedback in the physical world, by highlighting the corresponding folder in the filing cabinet. In this paper we describe the hardware and software implementation our prototype system, and present the results of a preliminary pilot study of its use

    An Overlapping Kinase and Phosphatase Docking Site Regulates Activity of the Retinoblastoma Protein

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    The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein (Rb) are modulated by a balance of kinase and phosphatase activities. Here we characterize the association of Rb with the catalytic subunit of protein phosphatase 1 (PP1c). A crystal structure identifies an enzyme docking site in the Rb C-terminal domain that is required for efficient PP1c activity toward Rb. The phosphatase docking site overlaps with the known docking site for cyclin-dependent kinase (Cdk), and PP1 competition with Cdk-cyclins for Rb binding is sufficient to retain Rb activity and block cell-cycle advancement. These results provide the first detailed molecular insights into Rb activation and establish a novel mechanism for Rb regulation in which kinase and phosphatase compete for substrate docking
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